This is often used for burn patients; skin is removed from one area of the body and transplanted to another. There are two types of skin graft: split-thickness grafts in which just a few layers of outer skin are transplanted and full-thickness grafts, which involve all of the dermis. There is usually permanent scarring that is noticeable.

During a skin graft, a special skin-cutting instrument known as a dermatone removes the skin from an area (the donor site) usually hidden by clothing such as the buttocks or inner thigh. Once removed, the graft is placed on the area in need of covering and held in place by a dressing and a few stitches. The donor site is also covered with a dressing to prevent infection from occurring. Recovery time from a split-thickness skin graft is generally fairly rapid, often less than three weeks. For full-thickness skin graft patients the recovery time is a few weeks longer. Aside from burn patients, skin grafts can also be used during breast or nose reconstruction.